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The mice were purchased from Razi Vaccine and Serum Research Institute in the southeastern of Iran, Kerman branch. The animals were kept in standard conditions (12 hr light: 12 hr dark and 22 ± 2°C), and underwent treatment at the Laboratory Animal House of the Veterinary Faculty of Shahid Bahonar University of Kerman, Iran, for at least one week before the treatment and during the experimental period. A total of 20 healthy adult female NMRI mice (aged 6–8 weeks, 27–31 g) were used in this study and fed with standard commercial laboratory chow ((pellet form), Javaneh Khorasan Co., Mashhad, Iran) and water ad libitum. All the investigations were conducted in accordance with the Guiding Principles for the Care and Use of Research Animals.

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