Solubility is described as the dissolution of solute in solvent to give a homogenous system, is one of the important parameters to attain desired concentration of drug in systemic circulation to obtain pharmacological response. Low aqueous solubility is the dominant issue faced with formulation development of unique chemical entities as well as for the generic development. The inadequate dissolution rate of the drug is the limiting factor in the oral bioavailability of poorly water soluble compounds. This review considered BCS classification, carriers for solubility enhancement and different techniques for solubility enhancement. Different techniques are used for the improvement of the solubility of poorly soluble drugs which include micronization, nanonization, sonocrystallization, supercritical fluid method, spray freezing into liquid and lyophilisation, evaporative precipitation into aqueous solution, use of surfactant, use of co-solvent, hydrotropy method, use of salt forms, solvent deposition, solubilising agents, modification of the crystal habit, co-crystallisation, complexation and drug dispersion in carriers. Choice of solubility developing method depends on drug property, site of absorption, and required dosage form characteristics. A success of formulation depends on how accurately it makes the drug available at the site of action. The objective of this review article is to describe the techniques of solubilisation for the fulfilment of effective absorption with improved bioavailability.


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