Baseline serum uric acid can be a guide for predicting acute kidney injury in sepsis.
Aim: Sepsis is the most important cause of acute kidney injury (AKI) in the intensive care unit (ICU) with 15%–20% of patients with sepsis-associated AKI prescribed renal replacement therapy. Uric acid has been linked to hypertension, dyslipidemia, fatty liver, renal disease, and cardiovascular disease. Uric acid levels are associated with an increased risk of AKI. Here, we explored whether elevated uric acid levels have a role in predicting AKI in sepsis.
Material and Method: This retrospective study enrolled 105 consecutive cases with sepsis admitted to the ICU in this retrospective study between October 2015 and December 2017. Clinical laboratory tests, and a new Simplified Acute Physiology Score (SAPSII) score were recorded on admission; renal function was monitored for seven consecutive days.
Results: The rate of AKI 7 days after enrollment was 47.6%. Baseline uric acid levels were higher in the AKI group (Group 1) than in the non-AKI group (Group 2) (p18 years and admission to the MICU with a working diagnosis of sepsis based on the Society of Critical Care Medicine, Surviving Sepsis Campaign 2012 definition12. Exclusion criteria included age